safinamide

Safinamide, sold under the brand name Xadago among others, is a medication used as treatment for Parkinson's disease with "off" episodes; it has multiple modes of action, including the inhibition of monoamine oxidase B.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 464386010
Drug.image: Safinamide.svg
Drug.image_class: skin-invert-image
Drug.width: 250
Drug.image2: Safinamide_3D_Xtal.png
Drug.width2: 230
Drug.tradename: Xadago, others
Drug.pregnancy_category: Fetal malformations in animal studies
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: N04
Drug.ATC_suffix

Article

11 sections

Contents

Medical uses
Contraindications
Adverse effects
Overdose
Interactions
Pharmacology
Mechanisms of action
Pharmacokinetics
History
Research
References

{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 464386010 | image = Safinamide.svg | image_class = skin-invert-image | width = 250 | alt = | image2 = Safinamide_3D_Xtal.png | width2 = 230 | tradename = Xadago, others | Drugs.com = | pregnancy_AU = | pregnancy_category = Fetal malformations in animal studies | routes_of_administration = By mouth | ATC_prefix = N04 | ATC_suffix = BD03 | ATC_supplemental = | legal_AU = S4 | legal_AU_comment = | legal_CA = Rx-only | legal_CA_comment = | legal_UK = POM | legal_UK_comment = | legal_US = Rx-only | legal_US_comment = | legal_EU = Rx-only | legal_EU_comment = | legal_status = | bioavailability = 95% | protein_bound = 88–90% | metabolism = Amidases, glucuronidation | metabolites = | onset = | elimination_half-life = 20–30 hrs | duration_of_action = | excretion = 76% Kidney, 1.5% faeces