CDH1

Name

cadherin 1

Type

protein-coding

Position

68,737,242–68,835,543 (+)

Aliases

Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO

Ensembl

ENSG00000039068

RefSeq RNA

NM_001317184.2, NM_001317185.2, NM_001317186.2, NM_004360.5

RefSeq protein

NP_001304113.1, NP_001304114.1, NP_001304115.1, NP_004351.1

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

cadherin 1

Symbol

CDH1

Biotype

Protein coding

Organism

Homo sapiens

Location

16:68,737,242-68,835,543

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

PBB Protein CDH1 image.jpg

via Wikidata · CC0