CDH10

Name

cadherin 10

Type

protein-coding

Position

24,485,606–24,644,987 (−)

Ensembl

ENSG00000040731

RefSeq RNA

NM_001190450.1, NM_001317222.2, NM_001317224.2, NM_001362460.1, NM_006727.5

RefSeq protein

NP_001304151.1, NP_001304153.1, NP_001349389.1, NP_006718.2, XP_011512225.1

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

cadherin 10

Symbol

CDH10

Biotype

Protein coding

Organism

Homo sapiens

Location

5:24,485,606-24,644,987

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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