NRCAM
Sign in to saveAlso known as neuronal cell adhesion molecule
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.
Gene data
NRCAM- Name
- neuronal cell adhesion molecule
- Type
- protein-coding
- Aliases
- NEDNMS
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- Protein NRCAM PDB 1uen.png
Show 5 more facts
- HomoloGene ID
- 21041
- exact match
- identifiers.org/ncbigene/4897
- genomic end
- 108097161
- genomic start
- 107788068
- cytogenetic location
- 7q31.1
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- Further reading
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.