NRCAM
Sign in to saveAlso known as neuronal cell adhesion molecule
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.
Gene data
NRCAM- Name
- neuronal cell adhesion molecule
- Type
- protein-coding
- Position
- 108,147,623–108,456,717 (−)
- Aliases
- NEDNMS
- Ensembl
- ENSG00000091129
- RefSeq RNA
- NM_001037132.4, NM_001037133.1, NM_001193582.2, NM_001193583.2, NM_001193584.2
- RefSeq protein
- NP_001032209.1, NP_001180511.1, NP_001180512.1, NP_001180513.1, NP_001358048.1
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
neuronal cell adhesion molecule
- Symbol
- NRCAM
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:108,147,623-108,456,717
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein NRCAM PDB 1uen.png
Show 8 more facts
- HomoloGene ID
- 21041
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4897
- genomic end
- 108097161
- genomic start
- 107788068
- chromosome
- human chromosome 7
- cytogenetic location
- 7q31.1
- expressed in
- amygdala
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “NRCAM” article, available under the CC BY-SA 4.0 licence.