CEA cell adhesion molecule 5
Sign in to saveAlso known as carcinoembryonic antigen-related cell adhesion molecule 5, meconium antigen 100, CEACAM5, Carcinoembryonic antigen, carcinoembryonic antigen related cell adhesion molecule 5, CEA, CD66e
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.
In the Vinony graph
Within Vinony's link graph, CEA cell adhesion molecule 5 is referenced by 363 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It is catalogued under topics including Clusters of differentiation and Genes on human chromosome 19.
Its subject is documented across 5 Wikipedia language editions.
Protein · UniProt
Cell adhesion molecule CEACAM5
- Gene
- CEACAM5
- Organism
- Homo sapiens (Human)
- Length
- 702 aa
- Molecular mass
- 76,796 Da
- Evidence
- 1: Evidence at protein level
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registeredWikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Functions
- See also
- References
- Further reading
- External links
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.
== Functions == In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer. Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells. Also, it plays a significant role in the inhibition of differentiation and apoptosis in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells. High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).
Excerpted from Wikipedia’s “CEA cell adhesion molecule 5” article, available under the CC BY-SA 4.0 licence.