CEA cell adhesion molecule 5
Sign in to saveAlso known as carcinoembryonic antigen-related cell adhesion molecule 5, meconium antigen 100, CEACAM5, Carcinoembryonic antigen, carcinoembryonic antigen related cell adhesion molecule 5, CEA, CD66e
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.
Protein · UniProt
Cell adhesion molecule CEACAM5
- Gene
- CEACAM5
- Organism
- Homo sapiens (Human)
- Length
- 702 aa
- Molecular mass
- 76,796 Da
- Evidence
- 1: Evidence at protein level
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registeredWikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Functions
- See also
- References
- Further reading
- External links
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.
== Functions == In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer. Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells. Also, it plays a significant role in the inhibition of differentiation and apoptosis in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells. High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).
Excerpted from Wikipedia’s “CEA cell adhesion molecule 5” article, available under the CC BY-SA 4.0 licence.