CEBPA
Sign in to saveAlso known as C/EBP-alpha, CEBP, CCAAT/enhancer binding protein alpha, CCAAT enhancer binding protein alpha
CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans. CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells. For details on the CCAAT structural motif in gene enhancers and on CCAAT/Enhancer Binding Proteins see the specific page.
Gene data
CEBPA- Name
- CCAAT enhancer binding protein alpha
- Type
- protein-coding
- Position
- 33,299,934–33,302,534 (−)
- Aliases
- C/EBP-alpha, CEBP
- Ensembl
- ENSG00000245848
- RefSeq RNA
- NM_001285829.2, NM_001287424.2, NM_001287435.2, NM_004364.5
- RefSeq protein
- NP_001272758.1, NP_001274353.1, NP_001274364.1, NP_004355.2
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
CCAAT enhancer binding protein alpha
- Symbol
- CEBPA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:33,299,934-33,302,534
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
2,331 papers- Prognostic impact of CEBPA mutational subgroups in adult AML.Leukemia · 2024
- CEBPA mutations in acute myeloid leukemia: implications in risk stratification and treatment.International journal of hematology · 2024
- Prognostic impact of CEBPA bZIP domain mutation in acute myeloid leukemia.Blood advances · 2022
- CEBPA mutations in AML: site matters.Blood · 2022
- CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome.Blood · 2022
via PubMed
Wikidata facts
- Image
- 1nwq.png
Show 5 more facts
- HomoloGene ID
- 3211
- exact match
- identifiers.org/ncbigene/1050
- genomic end
- 33302534
- genomic start
- 33790840
- cytogenetic location
- 19q13.11
Sources (9)
via Wikidata · CC0
~5 min read
Article
12 sectionsContents
- Function
- Common mutations
- Interactions
- Clinical significance
- Significance in acute myeloid leukemia
- Prognostic significance of CEBPA mutations
- Significance in solid tumors
- Methylation of CEBPA as a prognostic biomarker in AML patients
- See also
- References
- Further reading
- External links
CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans. CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells. For details on the CCAAT structural motif in gene enhancers and on CCAAT/Enhancer Binding Proteins see the specific page.
== Function ==