頭孢克洛

Also known as Ceclor, Panacef, Alfatil, CCL, Céfeaclor, Cefaclor anhydrous, Cephaclor, Cefacloro

Cefaclor, sold under the trade name Ceclor among others, is a second-generation cephalosporin antibiotic used to treat certain bacterial infections such as pneumonia and infections of the ear, lung, skin, throat, and urinary tract. It is also available from other manufacturers as a generic.

Chemical data

Formula: C15H14ClN3O4S
Molecular weight: 367.8 g/mol
IUPAC name: (6R,7R)-7-[[(2R)-2-azaniumyl-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)[NH3+])C(=O)[O-])Cl
InChIKey: QYIYFLOTGYLRGG-GPCCPHFNSA-N
XLogP: -1.1
Polar surface area: 142 Å²
H-bond donors: 2
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

1,949 papers

Cefaclor into the millennium.Journal of chemotherapy (Florence, Italy) · 1999
Cefaclor revisited.Clinical therapeutics · 2000
Evaluation of cefaclor.American journal of hospital pharmacy · 1981
Cefaclor reactions.Pediatric infectious disease · 1985
Cephalexin, Cefaclor, and Ampicillin: Points in the Picture of β-Lactam Cross-Reactivity.The journal of allergy and clinical immunology. In practice · 2022

via PubMed

Wikidata facts

Mass: 367.039355

Show 5 more facts

chemical formula: C₁₅H₁₄ClN₃O₄S
isomeric SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)Cl
canonical SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
defined daily dose: 1
Commons category: Cefaclor

Sources (6)

via Wikidata · CC0

Article · 中文

头孢克洛（英語：Cefaclor），商品名如希克劳，是第二代头孢类抗生素，用来治疗由细菌感染导致的症状如肺炎，化学名(6R,7R)-7-[(R)-2-氨基-2-苯乙酰氨基]-3-氯-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸，化学式C15H14ClN3O4S。頭孢克洛於1973年獲得專利，並於1979年被批准用於醫療方面。

Abstract from DBpedia / Wikipedia · CC BY-SA