Structure via PubChem · Public domain (PubChem)
头孢克肟
Sign in to saveAlso known as CL-284635, FK-027, FR-17027, cefixime anhydrous, (−)-cefixime, suprax
Cefixime, sold under the brand name Suprax among others, is an antibiotic medication used to treat a number of bacterial infections. These infections include otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease. For gonorrhea typically only one dose is required. In the United States it is a second-line treatment to ceftriaxone for gonorrhea. It is taken by mouth.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 460023156
- Drug.image
- Cefixime skeletal structure.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Cefixime ball-and-stick model from xtal 2013.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Suprax, others
- Drug.MedlinePlus
- a690007
- Drug.DailyMedID
- Cefixime
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- J01
- Drug.ATC_suffix
- DD08
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- 30 to 50%
via Wikipedia infobox
Chemical data
- Formula
- C16H15N5O7S2
- Molecular weight
- 453.5 g/mol
- IUPAC name
- (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- SMILES
- C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OCC(=O)O)/C3=CSC(=N3)N)SC1)C(=O)O
- InChIKey
- OKBVVJOGVLARMR-QSWIMTSFSA-N
- XLogP
- -0.7
- Polar surface area
- 238 Ų
- H-bond donors
- 4
- H-bond acceptors
- 12
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1989
- Admin. routes
- oral
- Indications
- Otitis media, infection, neoplasm, osteomyelitis
via ChEMBL · EBI
Wikidata facts
- Subclass of
- cephalosporin antibiotic
- Mass
- 453.04128982000003
- Has use
- medication
Show 9 more facts
- chemical formula
- C₁₆H₁₅N₅O₇S₂
- subject has role
- enzyme inhibitor
- medical condition treated
- otitis media
- canonical SMILES
- C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O
- isomeric SMILES
- C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OCC(=O)O)/C3=CSC(=N3)N)SC1)C(=O)O
- World Health Organisation international non-proprietary name
- cefixime
- NCI Thesaurus ID
- C1100
- defined daily dose
- 0.4
- Commons category
- Cefixime
Sources (7)
via Wikidata · CC0
Article · 中文
頭孢克肟（Cefixime），是一種抗生素，用於治療多種细菌感染，例如中耳炎、鏈球菌性咽炎、肺炎、泌尿道感染、淋病和萊姆病。治療淋病時通常只需口服一劑。在美國，本品是治療淋病的二線用藥，一線用藥是頭孢曲松（英語：ceftriaxone）。本品的給藥方式為口服。 常見的副作用為腹瀉、腹痛和有噁心感，可能的嚴重副作用則為出現過敏反應和引發偽膜性結腸炎。若患者曾有嚴重則不建議使用；但用於懷孕患者應該是安全的。本品是第三代的頭孢菌素類藥物，藥理機轉是藉由妨礙細菌的細胞壁生成，使細菌死亡。 1979年，頭孢克肟取得專利，1989 年在美國核可為醫藥用途。本品名列世界衛生組織本藥物標準清單，認可為醫療系統中最安全有效的必需藥物之一。在發展中國家，每劑批發價約在0.26到2.09美元之譜，2015年，美國的整套療程所需劑量約要價100到200美元。
Abstract from DBpedia / Wikipedia · CC BY-SA