cefminox

Also known as cefminoxum, CMNX, (6R,7S)-7-(2-(((S)-2-Amino-2-carboxyethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Cefminox (INN) is a second-generation cephalosporin antibiotic.

In the Vinony graph

Within Vinony's link graph, cefminox is referenced by 185 other articles, and connects out to antibiotic, Pseudomonas aeruginosa and ceftolozane/tazobactam.

Vinony files it under Cephalosporin antibiotics, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.

Its subject is documented across 10 Wikipedia language editions.

Chemical data

Formula: C16H21N7O7S3
Molecular weight: 519.6 g/mol
IUPAC name: (6R,7S)-7-[[2-[(2S)-2-amino-2-carboxyethyl]sulfanylacetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SMILES: CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)CSC[C@H](C(=O)O)N)OC)SC2)C(=O)O
InChIKey: JSDXOWVAHXDYCU-VXSYNFHWSA-N
XLogP: -4
Polar surface area: 279 Å²
H-bond donors: 4
H-bond acceptors: 14
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: bacterial disease

via ChEMBL · EBI

Research

141 papers

Cefminox sodium alleviates the high-fat high-sugar-fed mice's hepatic fatty accumulation via multiple pathways.Heliyon · 2023
Severe coagulopathy caused by cefminox sodium in a liver cirrhosis patient: a case report.Infectious agents and cancer · 2022
Cefminox versus Cefoxitin in Hysterectomy Prophylaxis : Clinical Efficacy and Serum and Tissue Concentrations.Clinical drug investigation · 1997
Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats.Frontiers in pharmacology · 2018
[New antimicrobial agent series XXIV: Cefminox].The Japanese journal of antibiotics · 1987

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 519.066

Show 4 more facts

chemical formula: C₁₆H₂₁N₇O₇S₃
isomeric SMILES: CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)CSC[C@H](C(=O)O)N)OC)SC2)C(=O)O
canonical SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)CSCC(C(=O)O)N)OC)SC2)C(=O)O
subject has role: antibiotic

Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

Spectrum
References

Cefminox (INN) is a second-generation cephalosporin antibiotic.

==Spectrum== Cefminox is a broad-spectrum, bactericidal cephalosporin antibiotic. It is especially effective against Gram-negative and anaerobic bacteria. The following represents MIC data for a few medically significant microorganisms. Clostridioides difficile: 2 - 4 μg/ml Escherichia coli: 0.125 - 16 μg/ml Pseudomonas aeruginosa: 256 μg/ml

Excerpted from Wikipedia’s “cefminox” article, available under the CC BY-SA 4.0 licence.