CGS 15943
Sign in to saveAlso known as CGS 15943A, CGS-15943, CGS15943
CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A, having a Ki of 3.3nM at A2A and 21nM at A1. It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative, instead being a triazoloquinazoline. Consequently, CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor, and so has more a specific pharmacological effects profile. It produces similar effects to caffeine in animal studies, though with higher potency.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 285.041738
Show 3 more facts
- chemical formula
- C₁₃H₈ClN₅O
- canonical SMILES
- C1=COC(=C1)C2=NN3C(=N2)C4=C(C=CC(=C4)Cl)N=C3N
- Commons category
- CGS-15943
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Encyclopedic overview
2 sectionsContents
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- References
CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A, having a Ki of 3.3nM at A2A and 21nM at A1. It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative, instead being a triazoloquinazoline. Consequently, CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor, and so has more a specific pharmacological effects profile. It produces similar effects to caffeine in animal studies, though with higher potency.
==See also== ATL-444 SCH-58261
Excerpted from Wikipedia’s “CGS 15943” article, available under the CC BY-SA 4.0 licence.