Structure via PubChem · Public domain (PubChem)
CGS 15943
Sign in to saveAlso known as CGS 15943A, CGS-15943, CGS15943
CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A, having a Ki of 3.3nM at A2A and 21nM at A1. It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative, instead being a triazoloquinazoline. Consequently, CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor, and so has more a specific pharmacological effects profile. It produces similar effects to caffeine in animal studies, though with higher potency.
In the Vinony graph
Vinony's link graph records 690 inbound references to CGS 15943, and connects out to adenosine receptor, Anatomical Therapeutic Chemical Classification System and 5-methoxy-N,N-diisopropyltryptamine.
It sits within the topics 2-Furyl compounds, Adenosine receptor antagonists and Chemical pages without DrugBank identifier.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C13H8ClN5O
- Molecular weight
- 285.69 g/mol
- IUPAC name
- 9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
- SMILES
- C1=COC(=C1)C2=NN3C(=N2)C4=C(C=CC(=C4)Cl)N=C3N
- InChIKey
- MSJODEOZODDVGW-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 82.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 285.041738
Show 3 more facts
- chemical formula
- C₁₃H₈ClN₅O
- canonical SMILES
- C1=COC(=C1)C2=NN3C(=N2)C4=C(C=CC(=C4)Cl)N=C3N
- Commons category
- CGS-15943
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A, having a Ki of 3.3nM at A2A and 21nM at A1. It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative, instead being a triazoloquinazoline. Consequently, CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor, and so has more a specific pharmacological effects profile. It produces similar effects to caffeine in animal studies, though with higher potency.
==See also== ATL-444 SCH-58261
Excerpted from Wikipedia’s “CGS 15943” article, available under the CC BY-SA 4.0 licence.