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Structure via PubChem · Public domain (PubChem)
chlormerodrin
Sign in to saveAlso known as 1-[3-(Chloromercuri)-2-methoxypropyl]urea, Chlormerodrine, Chlormerodrinum, Chlormerodrina, {3-[(aminocarbonyl)amino]-2-methoxypropyl}chloromercury, Mercloran, Neohydrin
Chlormerodrin is a mercurial diuretic commercially traded from 1952 until 1974 that was once used to treat patients with heart failure, but is no longer in widespread use. The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain and the 197Hg form was even considered a contender for 99mTc by some physicians, but was ultimately discontinued by the FDA in 1989.
Chemical data
- Formula
- C5H11ClHgN2O2
- Molecular weight
- 367.2 g/mol
- IUPAC name
- [3-(carbamoylamino)-2-methoxypropyl]-chloromercury
- SMILES
- COC(CNC(=O)N)C[Hg]Cl
- InChIKey
- BJFGVYCULWBXKF-UHFFFAOYSA-M
- Polar surface area
- 64.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- parenteral
via ChEMBL · EBI
Research
642 papers- 197Hg-chlormerodrin dosimetry.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 1968
- Antimicrobial activity of chlormerodrin.Journal of pharmaceutical sciences · 1979
- METABOLISM OF CHLORMERODRIN-HG203.Investigative urology · 1963
- The deposition of Hg203-chlormerodrin in experimental brain tumors.Journal of neurosurgery · 1971
- The distribution of chlormerodrin (neohydrin) in tissues of the rat and dog.The Journal of clinical investigation · 1956
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 368.021548
- Has use
- medication
Show 5 more facts
- chemical formula
- C₅H₁₁ClHgN₂O₂
- canonical SMILES
- COC(CNC(=O)N)C[Hg]Cl
- World Health Organisation international non-proprietary name
- chlormerodrin
- has characteristic
- bitterness
- Commons category
- Chlormerodrin
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Chlormerodrin is a mercurial diuretic commercially traded from 1952 until 1974 that was once used to treat patients with heart failure, but is no longer in widespread use. The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain and the 197Hg form was even considered a contender for 99mTc by some physicians, but was ultimately discontinued by the FDA in 1989.
== References ==
Excerpted from Wikipedia’s “chlormerodrin” article, available under the CC BY-SA 4.0 licence.