EntityQ2736402· pop 20· linked from 297 articles

demeclocycline

Demeclocycline (INN, BAN, USAN, brand name Declomycin) is a tetracycline antibiotic which was derived from a mutant strain of Streptomyces aureofaciens.

Key facts

Drug.verifiedrevid: 460775334
Drug.IUPAC_name: (2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione
Drug.image: Demeclocycline.svg
Drug.image_class: skin-invert-image
Drug.image2: Demeclocycline 3D.png
Drug.image_class2: bg-transparent
Drug.tradename: Declomycin
Drug.MedlinePlus: a682103
Drug.pregnancy_US: D
Drug.legal_status: Rx-only
Drug.routes_of_administration: Oral
Drug.bioavailability: 60–80%
Drug.protein_bound: 41–50%
Drug.metabolism: Hepatic
Drug.elimination_half life: 10–17 hours
Drug.excretion: Renal
Drug.CAS_number: 127-33-3
Drug.CAS_supplemental: (HCl)

via Wikipedia infobox

Research

1,075 papers

Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review.International journal of clinical practice · 2015
Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes.Frontiers in immunology · 2020
Demeclocycline-induced diabetes insipidus.JAMA · 1974
Renal effects of demeclocycline.JAMA · 1980
Demeclocycline-induced renal failure.Lancet (London, England) · 1977

via PubMed

Article

6 sections

Contents

Uses
Contraindications
Side effects and interactions
Mechanism of action
Brand names
References

Demeclocycline (INN, BAN, USAN, brand name Declomycin) is a tetracycline antibiotic which was derived from a mutant strain of Streptomyces aureofaciens.

==Uses== Demeclocycline is officially indicated for the treatment of various types of bacterial infections. It is used as an antibiotic in the treatment of Lyme disease, acne, and bronchitis. Resistance, though, is gradually becoming more common, and demeclocycline is now rarely used for treatment of infections.