chlorobutanol
Sign in to saveChlorobutanol (trichloro-2-methyl-2-propanol) is an organic compound with the formula . It is a specifically a chlorohydrin. Chlorobutanol acts as a preservative, sedative, hypnotic, and weak local anesthetic similar in nature to chloral hydrate; it also has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations. However, it retains antimicrobial activity at 0.05% in water. Chlorobutanol has been used in the anesthesia and euthanasia of aquatic invertebrates and various fishes. It
Research
362 papers- Chlorobutanol toxicity.The Annals of pharmacotherapy · 1996
- In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol.Toxics · 2022
- Chlorobutanol assay.Journal of the American Pharmaceutical Association. American Pharmaceutical Association · 1948
- [Chlorobutanol poisoning: about a case].Annales francaises d'anesthesie et de reanimation · 2010
- Summary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative Chlorobutanol.Drug safety · 2019
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Article
5 sectionsContents
- Synthesis
- Parthenogenesis
- Safety
- References
- External links
Chlorobutanol (trichloro-2-methyl-2-propanol) is an organic compound with the formula . It is a specifically a chlorohydrin. Chlorobutanol acts as a preservative, sedative, hypnotic, and weak local anesthetic similar in nature to chloral hydrate; it also has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations. However, it retains antimicrobial activity at 0.05% in water. Chlorobutanol has been used in the anesthesia and euthanasia of aquatic invertebrates and various fishes. It is a white, volatile solid with a camphor-like odor.
== Synthesis == thumb|left|Sublimed crystals of chlorobutanol Chlorobutanol was first synthesized in 1881 by the German chemist Conrad Willgerodt (1841–1930).