cholesteryl ester transfer protein

Protein · UniProt

Cholesteryl ester transfer protein

Gene

CETP

Organism

Homo sapiens (Human)

Length

493 aa

Molecular mass

54,756 Da

Evidence

1: Evidence at protein level

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641, PubMed:3281933, PubMed:3600759). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796)

• PHASE3COMPLETED
  Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying TherapiesNewAmsterdam Pharma · NCT05142722
• PHASE1COMPLETED
  Safety, Immunogenicity and Dose Response of ATH03, a New Vaccine Against the Cholesterol Ester Transfer Protein (CETP)Affiris AG · NCT01284582
• COMPLETED
  Genes Involved in Lipid DisordersNational Heart, Lung, and Blood Institute (NHLBI) · NCT02311335
• PHASE3COMPLETED
  Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.NewAmsterdam Pharma · NCT05425745
• PHASE3ACTIVE_NOT_RECRUITING
  REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modificationUniversity of Oxford · NCT01252953
• UNKNOWN
  Relationship Between CETP Deficiency and Atherosclerosis in Patients With HyperalphalipoproteinemiaOsaka University · NCT01916512

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

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