APOC1

Name

apolipoprotein C1

Type

protein-coding

Aliases

APOC1B, Apo-CI, ApoC-I, apo-CIB, apoC-IB

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016].

via MyGene.info

Wikidata facts

Image

Protein APOC1 PDB 1ioj.png

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