Structure via PubChem · Public domain (PubChem)
cloroqualone
Sign in to saveCloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its poten
Chemical data
- Formula
- C16H12Cl2N2O
- Molecular weight
- 319.2 g/mol
- IUPAC name
- 3-(2,6-dichlorophenyl)-2-ethylquinazolin-4-one
- SMILES
- CCC1=NC2=CC=CC=C2C(=O)N1C3=C(C=CC=C3Cl)Cl
- InChIKey
- SONHVLIDLXLSOL-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 318.033
Show 3 more facts
- chemical formula
- C₁₆H₁₂Cl₂N₂O
- canonical SMILES
- CCC1=NC2=CC=CC=C2C(=O)N1C3=C(C=CC=C3Cl)Cl
- Commons category
- Cloroqualone
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its potential for abuse and overdose.
== See also == Afloqualone Etaqualone Methylmethaqualone Mecloqualone Mebroqualone Diproqualone Gamma-Aminobutyric acid
Excerpted from Wikipedia’s “cloroqualone” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0