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Рецептор комплемента 2-го типа
Sign in to saveAlso known as complement component (3d/Epstein Barr virus) receptor 2, Epstein-Barr virus receptor, complement receptor type 2, CR2, Complement C3d receptor, complement component 3d receptor 2, EBV receptor, CD21
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, Рецептор комплемента 2-го типа is referenced by 456 other articles, and connects out to CD8, PubMed and B-cell.
Vinony files it under Complement system and Genes on human chromosome 1.
Its subject is documented across 10 Wikipedia language editions.
Protein · UniProt
Complement receptor type 2
- Gene
- CR2
- Organism
- Homo sapiens (Human)
- Length
- 1,033 aa
- Molecular mass
- 112,916 Da
- Evidence
- 1: Evidence at protein level
Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1 (PubMed:1849076, PubMed:21527715, PubMed:7753047). When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells (PubMed:21527715). This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling (PubMed:1383329, PubMe…
Swiss-Prot (reviewed) · via UniProt
Research
390 papers- C3-dependent effector functions of complement.Immunological reviews · 2023
- Structure of complement receptor (CR) 2 and CR2-C3d complexes.Biochemical Society transactions · 2002
- Association of complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 vaccine.AIDS (London, England) · 2020
- The Structure-Function Relationships of Complement Receptor Type 2 (CR2; CD21).Current protein & peptide science · 2016
- Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking.Journal of molecular biology · 2010
via PubMed
Wikidata facts
- Instance of
- protein
Show 3 more facts
- molecular function
- protein binding
- cell component
- plasma membrane
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
Article · Русский
Рецептор комплемента 2-го типа (CR2, CD21; англ. complement component (3d/Epstein Barr virus) receptor 2; CR2) — белок, участвующий в системе комплемента. Связывается с производными компонента комплемента 3 iC3b (инактивированный продукт C3b), C3dg и C3d. Продукт гена человека CR2.
Abstract from DBpedia / Wikipedia · CC BY-SA