CORO2A
Sign in to saveAlso known as CLIPINB, IR10, WDR2, coronin 2A
Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.
Gene data
CORO2A- Name
- coronin 2A
- Type
- protein-coding
- Position
- 98,120,975–98,193,206 (−)
- Aliases
- CLIPINB, IR10, WDR2
- Ensembl
- ENSG00000106789
- RefSeq RNA
- NM_003389.3, NM_052820.4, XM_011518986.4, XM_054363755.1
- RefSeq protein
- NP_003380.3, NP_438171.1, XP_011517288.1, XP_054219730.1
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2546
- exact match
- identifiers.org/ncbigene/7464
- genomic end
- 98192637
- genomic start
- 100883257
- cytogenetic location
- 9q22.33
Sources (3)
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- Further reading
Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].
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