CPSF2
Sign in to saveAlso known as CPSF100, cleavage and polyadenylation specific factor 2
Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene. This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation. The CPSF2 protein connects the two subunits of the complex, mCF and mPSF. Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function. This protein has been identified as an essential subunit of the complex as certain mutations in the re
In the Vinony graph
Within Vinony's link graph, CPSF2 is referenced by 3 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 5 Wikipedia language editions.
Gene data
CPSF2- Name
- cleavage and polyadenylation specific factor 2
- Type
- protein-coding
- Position
- 92,121,512–92,172,145 (+)
- Aliases
- CPSF100
- Ensembl
- ENSG00000165934
- RefSeq RNA
- NM_001322270.2, NM_001322271.2, NM_001322272.2, NM_017437.3
- RefSeq protein
- NP_001309199.1, NP_001309200.1, NP_001309201.1, NP_059133.1
Predicted to enable RNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in membrane. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cleavage and polyadenylation specific factor 2
- Symbol
- CPSF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:92,121,512-92,172,145
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex - Cleavage and polyadenylation specificity factor subunit 2 (2) 6URG.png
Show 8 more facts
- HomoloGene ID
- 6460
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/53981
- genomic end
- 92630755
- genomic start
- 92121969
- chromosome
- human chromosome 14
- cytogenetic location
- 14q32.12
- expressed in
- monocyte
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene. This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation. The CPSF2 protein connects the two subunits of the complex, mCF and mPSF. Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function. This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation.
==References==
Excerpted from Wikipedia’s “CPSF2” article, available under the CC BY-SA 4.0 licence.