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GeneQ18040510· pop 6· linked from 5 articles

CPSF3

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Also known as CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.

In the Vinony graph

Within Vinony's link graph, CPSF3 is referenced by 5 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CPSF3

Name: cleavage and polyadenylation specific factor 3
Type: protein-coding
Position: 9,423,623–9,473,117 (+)
Aliases: CPSF-73, CPSF73, NEDMHS, NEDMHSN
Ensembl: ENSG00000119203
RefSeq RNA: NM_001321833.2, NM_001321834.2, NM_001321835.2, NM_001321836.2, NM_016207.4
RefSeq protein: NP_001308762.1, NP_001308763.1, NP_001308764.1, NP_001308765.1, NP_057291.1

This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012].

Gene Ontology

Biological process

mRNA 3'-end processing by stem-loop binding and cleavage mRNA 3'-end processing by stem-loop binding and cleavage mRNA 3'-end processing by stem-loop binding and cleavage mRNA 3'-end processing mRNA 3'-end processing nuclear histone mRNA catabolic process co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway positive regulation of G1/S transition of mitotic cell cycle

Molecular function

RNA binding RNA binding RNA binding RNA endonuclease activity RNA endonuclease activity RNA endonuclease activity RNA endonuclease activity 5'-3' RNA exonuclease activity

Cellular component

nucleus nucleus nucleus nucleoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex

Pathways

mRNA surveillance pathway - Homo sapiens (human)Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNAs Derived from Intronless Transcripts Disease Infectious disease mRNA 3'-end processing Transport of Mature Transcript to Cytoplasm Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination RNA Polymerase II Transcription

via MyGene.info

Gene · Ensembl

cleavage and polyadenylation specific factor 3

Symbol: CPSF3
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:9,423,623-9,473,117
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein CPSF3 PDB 2i7t.png

Show 9 more facts

HomoloGene ID: 6499
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/51692
genomic end: 9613230
genomic start: 9423651
chromosome: human chromosome 2
cytogenetic location: 2p25.1
expressed in: islet of Langerhans
Commons category: Cleavage and polyadenylation specificity factor subunit 3

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

References
External links
Further reading

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.

==References==

Excerpted from Wikipedia’s “CPSF3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 2