CYP1A1

Name

cytochrome P450 family 1 subfamily A member 1

Type

protein-coding

Position

74,719,542–74,725,536 (−)

Aliases

AHH, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX

Ensembl

ENSG00000140465

RefSeq RNA

NM_000499.5, NM_001319216.2, NM_001319217.2

RefSeq protein

NP_000490.1, NP_001306145.1, NP_001306146.1

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].

via MyGene.info

Gene · Ensembl

cytochrome P450 family 1 subfamily A member 1

Symbol

CYP1A1

Biotype

Protein coding

Organism

Homo sapiens

Location

15:74,719,542-74,738,469

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0