CYP4B1

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. {| class="wikitable" style="background:white" |+ Mouse Mutant Alleles for Cyp4b1 |- | Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI | Cyp4b1 |- | Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. | CYP4B1tm1a(KOMP)Wtsi |- | colspan=2 | Example structure of targeted conditional mutant allele for this gene |- | colspan=2 | 650px|Molecular structure of Cyp4b1 region with inserted mutation sequence |- | colspan=2 | These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Cyp4b1: see Knockout mouse |}