CYP2B6

Name

cytochrome P450 family 2 subfamily B member 6

Type

protein-coding

Position

40,991,281–41,018,398 (+)

Aliases

CPB6, CYP2B, CYP2B7, CYPIIB6, EFVM, IIB1, P450

Ensembl

ENSG00000197408

RefSeq RNA

NM_000767.5

RefSeq protein

NP_000758.1

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cytochrome P450 family 2 subfamily B member 6

Symbol

CYP2B6

Biotype

Protein coding

Organism

Homo sapiens

Location

19:40,991,131-41,018,413

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0