DAZ2
Sign in to saveAlso known as pDP1678, deleted in azoospermia 2
Deleted in azoospermia protein 2 is a protein that in humans is encoded by the DAZ2 gene.
In the Vinony graph
Vinony's link graph records 5 inbound references to DAZ2, and connects out to PubMed, Y chromosome and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome Y.
Vinony links it to 6 Wikipedia language editions.
Gene data
DAZ2- Name
- deleted in azoospermia 2
- Type
- protein-coding
- Chromosome
- Y
- Position
- 23,219,447–23,291,356 (+)
- Aliases
- pDP1678
- Ensembl
- ENSG00000205944
- RefSeq RNA
- NM_001005785.2, NM_001005786.2, NM_001388493.1, NM_001388494.1, NM_001388495.1
- RefSeq protein
- NP_001005785.1, NP_001005786.2, NP_001375422.1, NP_001375423.1, NP_001375424.1
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
deleted in azoospermia 2
- Symbol
- DAZ2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr Y:23,219,447-23,291,356
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 86954
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57055
- chromosome
- human Y chromosome
- genomic start
- 26980008
- genomic end
- 27053183
- cytogenetic location
- Yq11.223
- expressed in
- urinary bladder
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Deleted in azoospermia protein 2 is a protein that in humans is encoded by the DAZ2 gene.
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “DAZ2” article, available under the CC BY-SA 4.0 licence.