DAB2

Also known as DOC-2, DOC2, DAB2, clathrin adaptor protein, DAB adaptor protein 2

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.

In the Vinony graph

Vinony's link graph records 12 inbound references to DAB2, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 5.

Vinony links it to 4 Wikipedia language editions.

Gene data

DAB2

Name: DAB adaptor protein 2
Type: protein-coding
Aliases: DOC-2, DOC2

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

via MyGene.info