DEFB127

Also known as C20orf73, DEF-27, DEFB-27, DEFB27, bA530N10.2, hBD-27, defensin beta 127

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.

In the Vinony graph

Within Vinony's link graph, DEFB127 is referenced by 2 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.

It sits within the topics Defensins and Genes on human chromosome 20.

Its subject is documented across 6 Wikipedia language editions.

Gene data

DEFB127

Name: defensin beta 127
Type: protein-coding
Position: 157,454–159,163 (+)
Aliases: C20orf73, DEF-27, DEFB-27, DEFB27, bA530N10.2, hBD-27
Ensembl: ENSG00000088782
RefSeq RNA: NM_139074.4
RefSeq protein: NP_620713.1

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014].

Gene Ontology

Biological process

defense response to bacterium innate immune response innate immune response defense response to Gram-negative bacterium defense response to Gram-negative bacterium antimicrobial humoral immune response mediated by antimicrobial peptide

Molecular function

protein binding

Cellular component

extracellular region

Pathways

Beta defensins Defensins Innate Immune System Immune System Antimicrobial peptides

via MyGene.info

Gene · Ensembl

defensin beta 127

Symbol: DEFB127
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:157,454-159,163
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 89142
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/140850
genomic end: 139804
genomic start: 157454
chromosome: human chromosome 20
cytogenetic location: 20p13

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.

Excerpted from Wikipedia’s “DEFB127” article, available under the CC BY-SA 4.0 licence.