Structure via PubChem · Public domain (PubChem)
deutetrabenazine
Sign in to saveAlso known as SD-809, SD809, tetrabenazine D6, Austedo
Deutetrabenazine, sold under the brand name Austedo, is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with Huntington's disease and tardive dyskinesia.
Chemical data
- Formula
- C19H27NO3
- Molecular weight
- 323.5 g/mol
- IUPAC name
- (3R,11bR)-3-(2-methylpropyl)-9,10-bis(trideuteriomethoxy)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one
- SMILES
- [2H]C([2H])([2H])OC1=C(C=C2[C@H]3CC(=O)[C@@H](CN3CCC2=C1)CC(C)C)OC([2H])([2H])[2H]
- InChIKey
- MKJIEFSOBYUXJB-VFJJUKLQSA-N
- XLogP
- 2.9
- Polar surface area
- 38.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 323.236754
- Has use
- medication
Show 5 more facts
- isotopically modified form of
- tetrabenazine
- legal status (medicine)
- boxed warning
- canonical SMILES
- CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
- chemical formula
- C₁₉H₂₇NO₃
- isomeric SMILES
- [2H]C([2H])([2H])OC1=C(C=C2[C@H]3CC(=O)[C@@H](CN3CCC2=C1)CC(C)C)OC([2H])([2H])[2H]
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
8 sectionsContents
- Efficacy
- Pharmacology
- Pharmacodynamics
- History
- Society and culture
- Legal status
- References
- Further reading
Deutetrabenazine, sold under the brand name Austedo, is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with Huntington's disease and tardive dyskinesia.
Chemically, deutetrabenazine is an isotopic isomer of tetrabenazine in which six hydrogen atoms have been replaced by deuterium atoms. The incorporation of deuterium slows the rate of drug metabolism, allowing less frequent dosing.
Excerpted from Wikipedia’s “deutetrabenazine” article, available under the CC BY-SA 4.0 licence.