dexmedetomidine
Sign in to saveAlso known as MPV 1440, Precedex®, (+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole, Dexmedetomidina, Dexmedetomidinum, Dexmedetomidin, Dexmédétomidine
Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation. Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses. It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder. It is administered as an intravenous solution or as a buccal or sublingual film.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458436659
- Drug.image
- Dexmedetomidine.svg
- Drug.image_class
- skin-invert-image
- Drug.caption
- Above: molecular structure of dexmedetomidine Below: 3D ball and stick representation of a dexmedetomidine molecule
- Drug.image2
- Dexmedetomidine_3D_Xtal.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Precedex, others
- Drug.DailyMedID
- Dexmedetomidine
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- Intravenous, sublingual, buccal
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- CM18
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Research
11,933 papers- Dexmedetomidine: present and future directions.Korean journal of anesthesiology · 2019
- A systematic review of dexmedetomidine pharmacology in pediatric patients.Clinical and translational science · 2024
- Dexmedetomidine and Perioperative Arrhythmias.Journal of cardiothoracic and vascular anesthesia · 2024
- Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.JAMA · 2012
- Dexmedetomidine in Palliative Care: A Versatile New Weapon Against Delirium and Pain-Systematic Review.Journal of palliative medicine · 2024
via PubMed
Wikidata facts
- Subclass of
- medetomidine
- Mass
- 200.131349
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₃H₁₆N₂
- isomeric SMILES
- CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C
- canonical SMILES
- CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C
- World Health Organisation international non-proprietary name
- dexmedetomidine
- defined daily dose
- 1
- significant drug interaction
- sodium oxybate
- Commons category
- Dexmedetomidine
via Wikidata · CC0
~7 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Intensive care unit sedation
- Procedural sedation
- Adjunct in general anesthesia
- Other
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Veterinary use
- References
Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation. Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses. It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder. It is administered as an intravenous solution or as a buccal or sublingual film.
Similar to clonidine, dexmedetomidine is a sympatholytic drug that acts as an agonist of α2-adrenergic receptors in certain parts of the brain. It was developed by Orion Pharma.
Excerpted from Wikipedia’s “dexmedetomidine” article, available under the CC BY-SA 4.0 licence.