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dimdazenil
Sign in to saveAlso known as EVT-201, Junoenil
Dimdazenil, sold under the brand name Junoenil, is a medication used in the treatment of insomnia in China. It is a benzodiazepine derivative and a partial positive allosteric modulator of the GABAA receptor with two- to four-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits.
Chemical data
- Formula
- C17H17ClN6O2
- Molecular weight
- 372.8 g/mol
- IUPAC name
- 7-chloro-3-[5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl]-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
- SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C(=CC=C3)Cl)C4=NOC(=N4)CN(C)C
- InChIKey
- JCYLWUVDHLVGER-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 80.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- medication
- Mass
- 372.110151
Show 2 more facts
- chemical formula
- C₁₇H₁₇ClN₆O₂
- canonical SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C(=CC=C3)Cl)C4=NOC(=N4)CN(C)C
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Medical use
- History
- References
Dimdazenil, sold under the brand name Junoenil, is a medication used in the treatment of insomnia in China. It is a benzodiazepine derivative and a partial positive allosteric modulator of the GABAA receptor with two- to four-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits.
==Medical use== Dimdazenil shows effectiveness in the treatment of insomnia, but has less intrinsic activity in comparison to currently-marketed benzodiazepines and the Z-drugs; however, it is thought that the lower efficacy may result in fewer side effects, such as motor incoordination. In China, dimdazenil is approved for short-term treatment of insomnia.
Excerpted from Wikipedia’s “dimdazenil” article, available under the CC BY-SA 4.0 licence.