Structure via PubChem · Public domain (PubChem)
meclonazepam
Sign in to saveMeclonazepam ('(S)-3-methylclonazepam') is a benzodiazepine derivative similar in structure to clonazepam. It was first discovered by a team at Hoffmann-La Roche in the 1970s. It has sedative and anxiolytic actions like those of other benzodiazepines, and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.
In the Vinony graph
Within Vinony's link graph, meclonazepam is referenced by 542 other articles, and connects out to benzodiazepine drug, alphenal and zapizolam.
It sits within the topics 2-Chlorophenyl compounds, Chemical pages without DrugBank identifier and Designer drugs.
Its subject is documented across 10 Wikipedia language editions.
Chemical data
- Formula
- C16H12ClN3O3
- Molecular weight
- 329.74 g/mol
- IUPAC name
- (3S)-5-(2-chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
59 papers- The anthelmintic meclonazepam activates a schistosome transient receptor potential channel.The Journal of biological chemistry · 2024
- Development of non-sedating antischistosomal benzodiazepines.bioRxiv : the preprint server for biology · 2024
- Development of non-sedating benzodiazepines with in vivo antischistosomal activity.Antimicrobial agents and chemotherapy · 2024
- Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni.bioRxiv : the preprint server for biology · 2024
- Identifying Metabolites of Meclonazepam by High-Resolution Mass Spectrometry Using Human Liver Microsomes, Hepatocytes, a Mouse Model, and Authentic Urine Samples.The AAPS journal · 2017
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 329.057
Show 4 more facts
- chemical formula
- C₁₆H₁₂ClN₃O₃
- canonical SMILES
- CC1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl
- isomeric SMILES
- C[C@H]1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl
- Commons category
- Meclonazepam
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Pharmacology
- Legal issues
- United Kingdom
- See also
- References
- Further reading
Meclonazepam ('(S)-3-methylclonazepam') is a benzodiazepine derivative similar in structure to clonazepam. It was first discovered by a team at Hoffmann-La Roche in the 1970s. It has sedative and anxiolytic actions like those of other benzodiazepines, and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.
Meclonazepam was never used as medicine and instead appeared online as a designer drug.
Excerpted from Wikipedia’s “meclonazepam” article, available under the CC BY-SA 4.0 licence.