meclonazepam
Meclonazepam ('(S)-3-methylclonazepam') is a benzodiazepine derivative similar in structure to clonazepam. It was first discovered by a team at Hoffmann-La Roche in the 1970s. It has sedative and anxiolytic actions like those of other benzodiazepines, and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.
Chemical data
- Formula
- C16H12ClN3O3
- Molecular weight
- 329.74 g/mol
- IUPAC name
- (3S)-5-(2-chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
via PubChem
Research
59 papers- The anthelmintic meclonazepam activates a schistosome transient receptor potential channel.The Journal of biological chemistry · 2024
- Development of non-sedating antischistosomal benzodiazepines.bioRxiv : the preprint server for biology · 2024
- Development of non-sedating benzodiazepines with in vivo antischistosomal activity.Antimicrobial agents and chemotherapy · 2024
- Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni.bioRxiv : the preprint server for biology · 2024
- Identifying Metabolites of Meclonazepam by High-Resolution Mass Spectrometry Using Human Liver Microsomes, Hepatocytes, a Mouse Model, and Authentic Urine Samples.
Article
6 sectionsContents
- Pharmacology
- Legal issues
- United Kingdom
- See also
- References
- Further reading
Meclonazepam ('(S)-3-methylclonazepam') is a benzodiazepine derivative similar in structure to clonazepam. It was first discovered by a team at Hoffmann-La Roche in the 1970s. It has sedative and anxiolytic actions like those of other benzodiazepines, and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.
Meclonazepam was never used as medicine and instead appeared online as a designer drug.