DLGAP5
Sign in to saveAlso known as DLG7, HURP, discs large homolog associated protein 5, DLG associated protein 5
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.
Gene data
DLGAP5- Name
- DLG associated protein 5
- Type
- protein-coding
- Position
- 55,148,110–55,191,608 (−)
- Aliases
- DLG7, HURP
- Ensembl
- ENSG00000126787
- RefSeq RNA
- NM_001146015.2, NM_014750.5, XM_017021840.3, XM_047432016.1, XM_054377137.1
- RefSeq protein
- NP_001139487.1, NP_055565.3, XP_016877329.1, XP_047287972.1, XP_054233112.1
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in several cellular components, including centrosome; cytosol; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8840
- exact match
- identifiers.org/ncbigene/9787
- genomic end
- 55191608
- genomic start
- 55614830
- cytogenetic location
- 14q22.3
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- References
- Further reading
- External links
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.
DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture. DGL7 is a part of Ran-dependent complex. Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. Expression of DGL7 is found in cancer and stem cells.