DLGAP5
Sign in to saveAlso known as DLG7, HURP, discs large homolog associated protein 5, DLG associated protein 5
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.
In the Vinony graph
Within Vinony's link graph, DLGAP5 is referenced by 3 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 6 Wikipedia language editions.
Gene data
DLGAP5- Name
- DLG associated protein 5
- Type
- protein-coding
- Position
- 55,132,272–55,191,627 (−)
- Aliases
- DLG7, HURP
- Ensembl
- ENSG00000126787
- RefSeq RNA
- NM_001146015.2, NM_014750.5, XM_017021840.3, XM_047432016.1, XM_054377137.1
- RefSeq protein
- NP_001139487.1, NP_055565.3, XP_016877329.1, XP_047287972.1, XP_054233112.1
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in several cellular components, including centrosome; cytosol; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DLG associated protein 5
- Symbol
- DLGAP5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:55,132,272-55,191,627
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 8840
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9787
- genomic end
- 55191608
- genomic start
- 55614830
- chromosome
- human chromosome 14
- cytogenetic location
- 14q22.3
- expressed in
- sperm
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.
DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture. DGL7 is a part of Ran-dependent complex. Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. Expression of DGL7 is found in cancer and stem cells.
Excerpted from Wikipedia’s “DLGAP5” article, available under the CC BY-SA 4.0 licence.