DNAJB1

Also known as HSPF1, Hdj1, Hsp40, RSPH16B, Sis1, DnaJ heat shock protein family (Hsp40) member B1

DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.

Gene data

DNAJB1

Name: DnaJ heat shock protein family (Hsp40) member B1
Type: protein-coding
Position: 14,513,789–14,560,391 (−)
Aliases: HSPF1, Hdj1, Hsp40, RSPH16B, Sis1
Ensembl: ENSG00000132002
RefSeq RNA: NM_001300914.2, NM_001313964.2, NM_006145.3, XM_006722733.3, XM_011527956.4
RefSeq protein: NP_001287843.1, NP_001300893.1, NP_006136.1, XP_006722796.1, XP_011526258.1

This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].