DNAJB4
Sign in to saveAlso known as DNAJW, DjB4, HLJ1, DnaJ heat shock protein family (Hsp40) member B4
DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.
Gene data
DNAJB4- Name
- DnaJ heat shock protein family (Hsp40) member B4
- Type
- protein-coding
- Aliases
- CMYO21, CMYP21, DNAJW, DjB4, HLJ1
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 100610
- exact match
- identifiers.org/ncbigene/11080
- genomic end
- 78483648
- genomic start
- 78444859
- cytogenetic location
- 1p31.1
Sources (4)
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Article
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- References
- Further reading
DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.
==References==