EHMT2
Sign in to saveAlso known as BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, euchromatic histone lysine methyltransferase 2
Gen der Spezies Homo sapiens
Gene data
EHMT2- Name
- euchromatic histone lysine methyltransferase 2
- Type
- protein-coding
- Chromosome
- HSCHR6_MHC_QBL_CTG1
- Position
- 3,135,732–3,153,671 (−)
- Aliases
- BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
- Ensembl
- ENSG00000232045
- RefSeq RNA
- NM_001289413.2, NM_001318833.2, NM_001363689.2, NM_001395160.1, NM_001395161.1
- RefSeq protein
- NP_001276342.1, NP_001305762.1, NP_001350618.1, NP_001382089.1, NP_001382090.1
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IIregulation of DNA replicationregulation of DNA replicationDNA methylation-dependent constitutive heterochromatin formationDNA methylation-dependent constitutive heterochromatin formationcellular response to starvationpeptidyl-lysine dimethylation
Molecular function
Pathways
Lysine degradation - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Epigenetic regulation of gene expressionGeneric Transcription PathwayCellular responses to stressSenescence-Associated Secretory Phenotype (SASP)Cellular SenescencePKMTs methylate histone lysinesChromatin modifying enzymesTranscriptional Regulation by TP53
via MyGene.info
Gene · Ensembl
euchromatic histone lysine methyltransferase 2
- Symbol
- EHMT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_MCF_CTG1:3,221,824-3,239,759
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein EHMT2 PDB 2o8j.png
Show 8 more facts
- HomoloGene ID
- 48460
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10919
- chromosome
- human chromosome 6
- genomic start
- 31847536
- genomic end
- 31865464
- cytogenetic location
- 6p21.33
- expressed in
- anterior cingulate cortex
Sources (4)
via Wikidata · CC0