EIF2AK2
Sign in to saveAlso known as PKR, PPP1R83, PRKR, eukaryotic translation initiation factor 2 alpha kinase 2, LEUDEN, DYT33
Gen der Spezies Homo sapiens
Gene data
EIF2AK2- Name
- eukaryotic translation initiation factor 2 alpha kinase 2
- Type
- protein-coding
- Position
- 37,099,210–37,157,688 (−)
- Aliases
- PKR, PPP1R83, PRKR
- Ensembl
- ENSG00000055332
- RefSeq RNA
- NM_001135651.3, NM_001135652.3, NM_002759.4, XM_011532987.3, XM_047445115.1
- RefSeq protein
- NP_001129123.1, NP_001129124.1, NP_002750.1, XP_011531289.1, XP_047301071.1
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 2 alpha kinase 2
- Symbol
- EIF2AK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:37,099,210-37,157,688
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 6d3k orange adp green mg.png
Show 7 more facts
- HomoloGene ID
- 48134
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5610
- genomic end
- 37157522
- genomic start
- 37326353
- chromosome
- human chromosome 2
- cytogenetic location
- 2p22.2
via Wikidata · CC0
Article · Deutsch
Die Proteinkinase R (PKR, R von RNA-aktiviert, auch eukaryotic translation initiation factor 2-alpha kinase 2, EIF2AK2) ist ein Enzym aus der Gruppe der Proteinkinasen, welche bei bestimmten Infektionen die Proteinbiosynthese hemmt. Die Proteinkinase R gehört zu den Restriktionsfaktoren, genauer zu den antiviralen Proteinen und ist ein wichtiger Bestandteil der angeborenen Immunantwort.
Abstract from DBpedia / Wikipedia · CC BY-SA