EIF2AK2
Sign in to saveAlso known as PKR, PPP1R83, PRKR, eukaryotic translation initiation factor 2 alpha kinase 2, LEUDEN, DYT33
gene umano
Gene data
EIF2AK2- Name
- eukaryotic translation initiation factor 2 alpha kinase 2
- Type
- protein-coding
- Position
- 37,099,210–37,157,688 (−)
- Aliases
- PKR, PPP1R83, PRKR
- Ensembl
- ENSG00000055332
- RefSeq RNA
- NM_001135651.3, NM_001135652.3, NM_002759.4, XM_011532987.3, XM_047445115.1
- RefSeq protein
- NP_001129123.1, NP_001129124.1, NP_002750.1, XP_011531289.1, XP_047301071.1
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021].
Gene Ontology
Biological process
positive regulation of cytokine productionpositive regulation of cytokine productionregulation of translational initiationnegative regulation of cell population proliferationresponse to virusnegative regulation of translationnegative regulation of translationpositive regulation of chemokine production
Molecular function
Pathways
Protein processing in endoplasmic reticulum - Homo sapiens (human)Necroptosis - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Measles - Homo sapiens (human)Influenza A - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)Herpes simplex virus 1 infection - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 2 alpha kinase 2
- Symbol
- EIF2AK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:37,099,210-37,157,688
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 6d3k orange adp green mg.png
Show 7 more facts
- HomoloGene ID
- 48134
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5610
- genomic end
- 37157522
- genomic start
- 37326353
- chromosome
- human chromosome 2
- cytogenetic location
- 2p22.2
via Wikidata · CC0