EIF4E

Also known as EIF4F, eIF-4E, eukaryotic translation initiation factor 4E, AUTS19, CBP, EIF4E1, EIF4EL1

gène de l'espèce Homo sapiens

In the Vinony graph

Vinony's link graph records 260 inbound references to EIF4E, and connects out to PubMed, translation and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 4.

Vinony links it to 10 Wikipedia language editions.

Gene data

EIF4E

Name: eukaryotic translation initiation factor 4E
Type: protein-coding
Position: 98,876,654–98,929,925 (−)
Aliases: AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
Ensembl: ENSG00000151247
RefSeq RNA: NM_001130678.4, NM_001130679.3, NM_001331017.2, NM_001968.5
RefSeq protein: NP_001124150.1, NP_001124151.1, NP_001317946.1, NP_001959.1

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].