EIF4E

Name

eukaryotic translation initiation factor 4E

Type

protein-coding

Position

98,876,654–98,929,925 (−)

Aliases

AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E

Ensembl

ENSG00000151247

RefSeq RNA

NM_001130678.4, NM_001130679.3, NM_001331017.2, NM_001968.5

RefSeq protein

NP_001124150.1, NP_001124151.1, NP_001317946.1, NP_001959.1

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

via MyGene.info

Gene · Ensembl

eukaryotic translation initiation factor 4E

Symbol

EIF4E

Biotype

Protein coding

Organism

Homo sapiens

Location

4:98,876,654-98,929,925

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein EIF4E PDB 1ej1.png

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