EIF4E
Sign in to saveAlso known as EIF4F, eIF-4E, eukaryotic translation initiation factor 4E, AUTS19, CBP, EIF4E1, EIF4EL1
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein in humans encoded by the EIF4E gene. eIF4E plays a central role in translation initiation and is involved in regulating protein synthesis. Its mRNA cap-binding activity influences a range of biological processes and disease states, making it an important target for therapeutic development, particularly in disorders characterized by aberrant protein production.
Gene data
EIF4E- Name
- eukaryotic translation initiation factor 4E
- Type
- protein-coding
- Position
- 98,876,654–98,929,925 (−)
- Aliases
- AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
- Ensembl
- ENSG00000151247
- RefSeq RNA
- NM_001130678.4, NM_001130679.3, NM_001331017.2, NM_001968.5
- RefSeq protein
- NP_001124150.1, NP_001124151.1, NP_001317946.1, NP_001959.1
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 4E
- Symbol
- EIF4E
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:98,876,654-98,929,925
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein EIF4E PDB 1ej1.png
Show 7 more facts
- HomoloGene ID
- 123817
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1977
- genomic end
- 98929133
- genomic start
- 98879276
- chromosome
- human chromosome 4
- cytogenetic location
- 4q23
via Wikidata · CC0
Article · 日本語
eIF4E（eukaryotic translation initiation factor 4E）は、ヒトではEIF4E遺伝子にコードされるタンパク質である。
Abstract from DBpedia / Wikipedia · CC BY-SA