ELOA
Sign in to saveAlso known as SIII, SIII p110, TCEB3A, TCEB3, transcription elongation factor B subunit 3, elongin A
Elongin A is a protein that in humans is encoded by the ELOA gene.
Gene data
ELOA- Name
- elongin A
- Type
- protein-coding
- Aliases
- ELOA1, SIII, SIII p110, TCEB3, TCEB3A
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 37746
- exact match
- identifiers.org/ncbigene/6924
- genomic end
- 24088549
- genomic start
- 23743448
- cytogenetic location
- 1p36.11
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Elongin A is a protein that in humans is encoded by the ELOA gene.
Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel–Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.