ELP3

Also known as KAT9, elongator acetyltransferase complex subunit 3

Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene. ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex. In mammals, ELP3 is important for paternal DNA demethylation after fertilization. ELP3 is potentially involved in cellular redox homeostasis by medi

In the Vinony graph

Vinony's link graph records 3 inbound references to ELP3, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 5 Wikipedia language editions.

Gene data

ELP3

Name: elongator acetyltransferase complex subunit 3
Type: protein-coding
Position: 28,089,673–28,191,156 (+)
Aliases: KAT9
Ensembl: ENSG00000134014
RefSeq RNA: NM_001284220.2, NM_001284222.2, NM_001284224.2, NM_001284225.2, NM_001284226.2
RefSeq protein: NP_001271149.1, NP_001271151.1, NP_001271153.1, NP_001271154.1, NP_001271155.1

ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]