ELP3
Sign in to saveAlso known as KAT9, elongator acetyltransferase complex subunit 3
Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene. ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex. In mammals, ELP3 is important for paternal DNA demethylation after fertilization. ELP3 is potentially involved in cellular redox homeostasis by medi
Gene data
ELP3- Name
- elongator acetyltransferase complex subunit 3
- Type
- protein-coding
- Aliases
- KAT9
ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]
via MyGene.info
Gene · Ensembl
elongator acetyltransferase complex subunit 3
- Symbol
- ELP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:28,089,673-28,191,156
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/55140
- HomoloGene ID
- 7105
- genomic end
- 28048673
- genomic start
- 27947190
- cytogenetic location
- 8p21.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene. ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex. In mammals, ELP3 is important for paternal DNA demethylation after fertilization. ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation of glucose-6-phosphate dehydrogenase. Besides, ELP3 may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
==References==