File:Minoxidil_structure.svg · Wikimedia Commons · See Wikimedia Commons
minoxidil
Sign in to saveAlso known as Rogaine®, 2,4-Diamino-6-piperidinopyrimidine 3-oxide, Minossidile, Minoxidilum, Tricoxidil, Minoximen, Regaine
Minoxidil, sold under the brand names Loniten and Rogaine among others, is a medication used for the treatment of high blood pressure and pattern hair loss. It is an antihypertensive and a vasodilator. It is available as a generic medication by prescription in oral tablet form and over-the-counter as a topical liquid or foam.
Key facts
- Drug.image
- Minoxidil structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 150
- Drug.alt
- A space filling model of the molecule
- Drug.image2
- Minoxidil-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 135
- Drug.tradename
- Loniten, Rogaine, others
- Drug.MedlinePlus
- a682608
- Drug.DailyMedID
- Minoxidil
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- Oral, sublingual, topical (solution, foam, spray)
- Drug.class
- Potassium channel opener; KATP channel opener
- Drug.ATC_prefix
- C02
- Drug.ATC_suffix
- DC01
- Drug.legal_AU
- S4
- Drug.legal_AU_comment
- / S2
- Drug.legal_UK
- GSL
via Wikipedia infobox
Chemical data
- Formula
- C9H15N5O
- Molecular weight
- 209.25 g/mol
- IUPAC name
- 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
- SMILES
- C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
- InChIKey
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 88.9 Ų
- H-bond donors
- 3
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 209.1277
Show 6 more facts
- chemical formula
- C₉H₁₅N₅O
- World Health Organisation international non-proprietary name
- minoxidil
- canonical SMILES
- C1=C([N+](=C(N=C1N2CCCCC2)N)[O-])N
- defined daily dose
- 20
- MCN code
- 2933.59.91
- Commons category
- Minoxidil
via Wikidata · CC0
~24 min read
Article
31 sectionsContents
- Medical uses
- High blood pressure
- Hair loss
- Available forms
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Chemistry
- Properties
- Synthesis
- History
- Initial development
- Repurposing for hair growth
- Society and culture
- Economics
- Brand names
- Research
- Hair loss
- Beard growth
- Nail problems
- Other uses
- Toxicity to animals
- References
- External links
Minoxidil, sold under the brand names Loniten and Rogaine among others, is a medication used for the treatment of high blood pressure and pattern hair loss. It is an antihypertensive and a vasodilator. It is available as a generic medication by prescription in oral tablet form and over-the-counter as a topical liquid or foam.
==Medical uses== ===High blood pressure=== Minoxidil, when used for hypertension, is generally reserved for use in severe hypertension patients who do not respond to at least two agents and a diuretic. Minoxidil is also generally administered with a loop diuretic to prevent sodium retention and potassium retention. It may also cause a reflex tachycardia and thus is prescribed with a beta blocker.