epithelial cell adhesion molecule
Sign in to saveAlso known as EGP, adenocarcinoma-associated antigen, hEGP314, Epithelial cell surface antigen, tumor-associated calcium signal transducer 1, EGP314, cell surface glycoprotein Trop-1
mammalian protein found in Homo sapiens
Protein · UniProt
Epithelial cell adhesion molecule
- Gene
- EPCAM
- Organism
- Homo sapiens (Human)
- Length
- 314 aa
- Molecular mass
- 34,932 Da
- Evidence
- 1: Evidence at protein level
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E
3D-structureCell junctionCell membraneDirect protein sequencingDisease variantDisulfide bondGlycoproteinHereditary nonpolyposis colorectal cancer
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
8,795 papers- Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule.The American journal of pathology · 2007
- Multifaceted Approaches in Epithelial Cell Adhesion Molecule-Mediated Circulating Tumor Cell Isolation.Molecules (Basel, Switzerland) · 2025
- Clinicopathologic implications of epithelial cell adhesion molecule expression across molecular subtypes of breast carcinoma.Journal of cancer research and therapeutics · 2020
- Deglycosylation of epithelial cell adhesion molecule affects epithelial to mesenchymal transition in breast cancer cells.Journal of cellular physiology · 2019
- Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Tumor Spheroids of Human Colorectal Adenocarcinoma Cells.Bulletin of experimental biology and medicine · 2020
via PubMed
Clinical Trials
10 registered- NARECRUITINGAn Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test ResultsMemorial Sloan Kettering Cancer Center · NCT05420064
- PHASE1RECRUITINGPhase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.BioAtla, Inc. · NCT05808634
- PHASE1UNKNOWNIntraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)Jian-Kun Hu · NCT03563326
- UNKNOWNImmunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Epithelial Ovarian CarcinomaSohag University · NCT05576519
- COMPLETEDIdentification of Circulating Tumor Cells in the Peripheral Blood of Lung Cancer PatientsStanford University · NCT00568282
- NAACTIVE_NOT_RECRUITINGSurgery in Preventing Ovarian Cancer in Patients With Genetic MutationsM.D. Anderson Cancer Center · NCT02760849
Wikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
via Wikidata · CC0