epithelial cell adhesion molecule
Sign in to saveAlso known as EGP, adenocarcinoma-associated antigen, hEGP314, Epithelial cell surface antigen, tumor-associated calcium signal transducer 1, EGP314, cell surface glycoprotein Trop-1
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, epithelial cell adhesion molecule is referenced by 639 other articles, and connects out to epithelium, PubMed and carcinoma.
Vinony files it under Clusters of differentiation and Genes on human chromosome 2.
Its subject is documented across 7 Wikipedia language editions.
Protein · UniProt
Epithelial cell adhesion molecule
- Gene
- EPCAM
- Organism
- Homo sapiens (Human)
- Length
- 314 aa
- Molecular mass
- 34,932 Da
- Evidence
- 1: Evidence at protein level
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E
Swiss-Prot (reviewed) · via UniProt
Research
8,795 papers- Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule.The American journal of pathology · 2007
- Multifaceted Approaches in Epithelial Cell Adhesion Molecule-Mediated Circulating Tumor Cell Isolation.Molecules (Basel, Switzerland) · 2025
- Clinicopathologic implications of epithelial cell adhesion molecule expression across molecular subtypes of breast carcinoma.Journal of cancer research and therapeutics · 2020
- Deglycosylation of epithelial cell adhesion molecule affects epithelial to mesenchymal transition in breast cancer cells.Journal of cellular physiology · 2019
- Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Tumor Spheroids of Human Colorectal Adenocarcinoma Cells.Bulletin of experimental biology and medicine · 2020
via PubMed
Clinical Trials
10 registered- NARECRUITINGAn Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test ResultsMemorial Sloan Kettering Cancer Center · NCT05420064
- PHASE1RECRUITINGPhase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.BioAtla, Inc. · NCT05808634
- PHASE1UNKNOWNIntraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)Jian-Kun Hu · NCT03563326
- UNKNOWNImmunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Epithelial Ovarian CarcinomaSohag University · NCT05576519
- COMPLETEDIdentification of Circulating Tumor Cells in the Peripheral Blood of Lung Cancer PatientsStanford University · NCT00568282
- NAACTIVE_NOT_RECRUITINGSurgery in Preventing Ovarian Cancer in Patients With Genetic MutationsM.D. Anderson Cancer Center · NCT02760849
Wikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
via Wikidata · CC0