Structure via PubChem · Public domain (PubChem)
resmetirom
Sign in to saveAlso known as MGL-3196
Resmetirom, sold under the brand name Rezdiffra, is a medication used to treat a form of fatty liver disease. Specifically it is used in the treatment of noncirrhotic metabolic dysfunction associated steatohepatitis (MASH) (formerly known as nonalcoholic steatohepatitis NASH). It is structurally similar to the thyroid hormone triiodothyronine and acts as an agonist of the thyroid hormone receptor beta (NR1A2).
Chemical data
- Formula
- C17H12Cl2N6O4
- Molecular weight
- 435.2 g/mol
- IUPAC name
- 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile
- SMILES
- CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
- InChIKey
- FDBYIYFVSAHJLY-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 136 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2024
- Admin. routes
- oral
- Indications
- non-alcoholic fatty liver disease, familial hypercholesterolemia, non-alcoholic steatohepatitis, Abnormal circulating lipid concentration
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 434.03
Show 3 more facts
- canonical SMILES
- CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
- chemical formula
- C₁₇H₁₂Cl₂N₆O₄
- Commons category
- Resmetirom
Sources (1)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- History
- Society and culture
- Legal status
- Research
- References
Resmetirom, sold under the brand name Rezdiffra, is a medication used to treat a form of fatty liver disease. Specifically it is used in the treatment of noncirrhotic metabolic dysfunction associated steatohepatitis (MASH) (formerly known as nonalcoholic steatohepatitis NASH). It is structurally similar to the thyroid hormone triiodothyronine and acts as an agonist of the thyroid hormone receptor beta (NR1A2).
The most common side effects include diarrhea and nausea.
Excerpted from Wikipedia’s “resmetirom” article, available under the CC BY-SA 4.0 licence.