EPS15
Sign in to saveAlso known as AF-1P, AF1P, MLLT5, epidermal growth factor receptor pathway substrate 15
Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.
Gene data
EPS15- Name
- epidermal growth factor receptor pathway substrate 15
- Type
- protein-coding
- Position
- 51,354,263–51,519,387 (−)
- Aliases
- AF-1P, AF1P, MLLT5
- Ensembl
- ENSG00000085832
- RefSeq RNA
- NM_001159969.2, NM_001410796.1, NM_001410797.1, NM_001981.3, XM_017000616.3
- RefSeq protein
- NP_001153441.1, NP_001397725.1, NP_001397726.1, NP_001972.1, XP_016856105.1
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
epidermal growth factor receptor pathway substrate 15
- Symbol
- EPS15
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:51,354,263-51,519,387
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein EPS15 PDB 1c07.png
Show 9 more facts
- HomoloGene ID
- 128359
- genetic association
- allergy
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2060
- genomic end
- 51519266
- genomic start
- 51819935
- chromosome
- human chromosome 1
- cytogenetic location
- 1p32.3
- expressed in
- pons
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.
== Function ==
Excerpted from Wikipedia’s “EPS15” article, available under the CC BY-SA 4.0 licence.