Also known as CRKII, p38, v-crk avian sarcoma virus CT10 oncogene homolog, CRK proto-oncogene, adaptor protein
protein-coding gene in the species Homo sapiens
Gene data
CRK- Name
- CRK proto-oncogene, adaptor protein
- Type
- protein-coding
- Aliases
- CRKII, p38
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
CRK proto-oncogene, adaptor protein
- Symbol
- CRK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:1,420,689-1,463,162
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CRK PDB 1b07.png
Show 5 more facts
- HomoloGene ID
- 81850
- exact match
- identifiers.org/ncbigene/1398
- genomic end
- 1366456
- genomic start
- 1323983
- cytogenetic location
- 17p13.3
via Wikidata · CC0