ret proto-oncogene

Also known as RET transforming sequence, cadherin-related family member 16, RET receptor tyrosine kinase, RET, rearranged during transfection, receptor tyrosine kinase, proto-oncogene tyrosine-protein kinase receptor Ret, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)

mammalian protein found in Homo sapiens

Protein · UniProt

Proto-oncogene tyrosine-protein kinase receptor Ret

Gene: RET
Organism: Homo sapiens (Human)
Length: 1,114 aa
Molecular mass: 124,319 Da
Evidence: 1: Evidence at protein level

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, Pub…

3D-structureAlternative splicingATP-bindingCell adhesionCell membraneChromosomal rearrangementDisease variantDisulfide bond

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

2 registered

UNKNOWN
Prospective Study on Resistance-associated Mutations in Metastatic Lung CancerUniversity of Milano Bicocca · NCT06081270
NOT_YET_RECRUITING
RET-US Study - Ultrasound-Based Prediction of RET Alterations and Lateral-Neck Metastasis in Thyroid CancerFujian Medical University · NCT07042984

via ClinicalTrials.gov

Wikidata facts

Instance of: protein
Has part: cadherin

Show 3 more facts

found in taxon: Homo sapiens
exact match: purl.uniprot.org/uniprot/P07949
physically interacts with: vandetanib

Sources (4)

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