epidermal growth factor receptor
Sign in to saveAlso known as erb-b2 receptor tyrosine kinase 1, cell proliferation-inducing protein 61, receptor tyrosine-protein kinase erbB-1, epidermal growth factor receptor tyrosine kinase domain, EGFR, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, proto-oncogene c-ErbB-1, cell growth inhibiting protein 40
mammalian protein found in Homo sapiens
Protein · UniProt
Epidermal growth factor receptor
- Gene
- EGFR
- Organism
- Homo sapiens (Human)
- Length
- 1,210 aa
- Molecular mass
- 134,277 Da
- Evidence
- 1: Evidence at protein level
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphoryla…
Swiss-Prot (reviewed) · via UniProt
Research
120,016 papers- Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors.Current topics in medicinal chemistry · 2020
- Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.Oncogene · 2018
- Epidermal growth factor receptor in asthma: A promising therapeutic target?Respiratory medicine · 2023
- Updates on the treatment of epidermal growth factor receptor-mutant non-small cell lung cancer.Cancer · 2025
- Epidermal growth factor receptor (EGFR)-targeted therapies in mesothelioma.Expert opinion on drug delivery · 2019
via PubMed
Clinical Trials
1,059 registered- PHASE2TERMINATEDWindow of Opportunity Trial of Dasatinib in Operable Triple Negative Breast Cancers With nEGFRUniversity of Wisconsin, Madison · NCT02720185
- PHASE2TERMINATEDA Study Of Oral GW572016 In Advanced Or Metastatic Non-Small Cell Lung CancerGlaxoSmithKline · NCT00073008
- NACOMPLETEDTetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for CancerAlliance for Clinical Trials in Oncology · NCT00091247
- NAUNKNOWNBlood Detection of EGFR Mutation For Iressa TreatmentPeking University Cancer Hospital & Institute · NCT02282267
- PHASE2COMPLETEDIressa Re-Challenge in Advanced NSCLC EGFR M+ Patients Who Responded to Gefitinib USed as 1st Line or Previous TreatmentAstraZeneca · NCT01530334
- PHASE1WITHDRAWNPhase I Trial of Vandetanib Combined With 131I-mIBG to Treat Patients With Advanced Phaeochromocytoma and ParagangliomaUniversity College, London · NCT01941849
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/P00533
- found in taxon
- Homo sapiens
- Commons category
- Epidermal growth factor receptor
via Wikidata · CC0