epidermal growth factor receptor
Sign in to saveAlso known as erb-b2 receptor tyrosine kinase 1, cell proliferation-inducing protein 61, receptor tyrosine-protein kinase erbB-1, epidermal growth factor receptor tyrosine kinase domain, EGFR, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, proto-oncogene c-ErbB-1, cell growth inhibiting protein 40
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, epidermal growth factor receptor is referenced by 931 other articles, and connects out to Erb-b2 receptor tyrosine kinase 2, protein dimer and ERBB4.
Vinony files it under Genes on human chromosome 7, Oncogenes and Tyrosine kinase receptors.
Its subject is documented across 23 Wikipedia language editions.
Protein · UniProt
Epidermal growth factor receptor
- Gene
- EGFR
- Organism
- Homo sapiens (Human)
- Length
- 1,210 aa
- Molecular mass
- 134,277 Da
- Evidence
- 1: Evidence at protein level
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphoryla…
Swiss-Prot (reviewed) · via UniProt
Research
120,016 papers- Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors.Current topics in medicinal chemistry · 2020
- Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.Oncogene · 2018
- Epidermal growth factor receptor in asthma: A promising therapeutic target?Respiratory medicine · 2023
- Updates on the treatment of epidermal growth factor receptor-mutant non-small cell lung cancer.Cancer · 2025
- Epidermal growth factor receptor (EGFR)-targeted therapies in mesothelioma.Expert opinion on drug delivery · 2019
via PubMed
Clinical Trials
1,059 registered- PHASE2TERMINATEDWindow of Opportunity Trial of Dasatinib in Operable Triple Negative Breast Cancers With nEGFRUniversity of Wisconsin, Madison · NCT02720185
- PHASE2TERMINATEDA Study Of Oral GW572016 In Advanced Or Metastatic Non-Small Cell Lung CancerGlaxoSmithKline · NCT00073008
- NACOMPLETEDTetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for CancerAlliance for Clinical Trials in Oncology · NCT00091247
- NAUNKNOWNBlood Detection of EGFR Mutation For Iressa TreatmentPeking University Cancer Hospital & Institute · NCT02282267
- PHASE2COMPLETEDIressa Re-Challenge in Advanced NSCLC EGFR M+ Patients Who Responded to Gefitinib USed as 1st Line or Previous TreatmentAstraZeneca · NCT01530334
- PHASE1WITHDRAWNPhase I Trial of Vandetanib Combined With 131I-mIBG to Treat Patients With Advanced Phaeochromocytoma and ParagangliomaUniversity College, London · NCT01941849
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/P00533
- found in taxon
- Homo sapiens
- Commons category
- Epidermal growth factor receptor
via Wikidata · CC0