Structure via PubChem · Public domain (PubChem)
エタゾラート
Sign in to saveAlso known as EHT-0202, SQ 20009
Etazolate (SQ-20,009, EHT-0202) is an anxiolytic drug which is a pyrazolopyridine derivative and has unique pharmacological properties. It acts as a positive allosteric modulator of the GABAA receptor at the barbiturate binding site, as an adenosine antagonist of the A1 and A2 subtypes, and as a phosphodiesterase inhibitor selective for the PDE4 isoform. It is currently in clinical trials for the treatment of Alzheimer's disease.
Chemical data
- Formula
- C14H19N5O2
- Molecular weight
- 289.33 g/mol
- IUPAC name
- ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate
- SMILES
- CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC
- InChIKey
- OPQRBXUBWHDHPQ-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 81.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Alzheimer disease
via ChEMBL · EBI
Research
109 papers- Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis.Neuroscience · 2021
- Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice.Neuroscience · 2014
- Etazolate rescues behavioral deficits in chronic unpredictable mild stress model: modulation of hypothalamic-pituitary-adrenal axis activity and brain-derived neurotrophic factor level.Neurochemistry international · 2013
- Phosphodiesterase 4 regulates pyroptosis in subarachnoid hemorrhage.Neural regeneration research · 2026
- Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones.Behavioural brain research · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 289.153875
Show 4 more facts
- chemical formula
- C₁₄H₁₉N₅O₂
- canonical SMILES
- CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC
- subject has role
- phosphodiesterase inhibitor
- Commons category
- Etazolate
Sources (2)
via Wikidata · CC0