Gene data
ETS2- Name
- ETS proto-oncogene 2, transcription factor
- Type
- protein-coding
- Position
- 38,805,115–38,824,956 (+)
- Aliases
- ETS2IT1
- Ensembl
- ENSG00000157557
- RefSeq RNA
- NM_001256295.2, NM_005239.6, XM_005260935.2, XM_017028290.2, XM_054324370.1
- RefSeq protein
- NP_001243224.1, NP_005230.1, XP_005260992.1, XP_016883779.1, XP_054180345.1
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IIskeletal system developmentregulation of DNA-templated transcriptionregulation of transcription by RNA polymerase IIregulation of transcription by RNA polymerase IIcell differentiationpositive regulation of transcription by RNA polymerase IIpositive regulation of transcription by RNA polymerase II
Molecular function
RNA polymerase II transcription regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription repressor activity, RNA polymerase II-specificDNA bindingDNA bindingDNA-binding transcription factor activity
Cellular component
Pathways
Ras signaling pathway - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Cellular responses to stressCellular SenescenceOncogene Induced SenescenceCellular responses to stimuliMyometrial relaxation and contraction pathwaysRas signalingExtracellular vesicles in the crosstalk of cardiac cells
via MyGene.info
Gene · Ensembl
ETS proto-oncogene 2, transcription factor
- Symbol
- ETS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 21:38,805,115-38,824,956
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ETS2 PDB 1k78.png
Show 7 more facts
- HomoloGene ID
- 3838
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2114
- genomic end
- 40196879
- genomic start
- 38805183
- chromosome
- human chromosome 21
- cytogenetic location
- 21q22.2
Sources (3)
via Wikidata · CC0